Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
CD80/CD86
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
NIH
Experimental treatment group (EG):
anti-CD80 and anti-CD86
Lethal infection (Con):
no
Lethal infection (EG):
N.I.
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Decreased peak and developed a chronic, low parasitemia (~1%)
Additional phenotypes (EG vs Con):
↑ IFN-g production by splenic T cells in vitro compared to anti-CD86 treatment alone, ↓ IL-4 production by splenic T cells in vitro; ↓ IgG1
Refs:
Taylor-Robinson et al., 1999, Immunology
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