Molecular group:
Signal transduction and intracellular danger sensors
Molecule/Cell:
MyD88
Plasmodium strain:
Plasmodium yoelii 17XNL
pRBC infection titer:
5 x 10^6
Mouse genetic background (Con):
N.I.
Level of backcrossing:
N.I.
Experimental treatment group (EG):
MyD88 -/-
Lethal infection (Con):
no
Lethal infection (EG):
37.5%
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Increased
Additional phenotypes (EG vs Con):
↓ serum IL-12p40 and similar IL-18 6 days p.i.; similar number of CD62Llow+CD4+ and CD69+CD4+ T cells in the spleen 6 days p.i.; no difference in [3H]thymidine uptake upon stimulation of splenocytes with anti-CD3; ↓ production of IL-12p40, IFN-g and similar IL-10 after stimulation of splenocytes isolated 6 days p.i. with anti-CD3 (similar IFN-g and IL-10 production compared to IL-18 -/-)
Refs:
Cramer et al., 2008, Microbes Infect
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