Molecular group:
Signal transduction and intracellular danger sensors
Molecule/Cell:
MyD88
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^6
Mouse genetic background (Con):
BALB/c
Level of backcrossing:
Backcrossed for 8 generations
Experimental treatment group (EG):
MyD88 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Liver pathology
Pathology (EG):
No liverpathology
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar serum IL-18; ↓ serum IL-12p40 and GPT (ALT); no liver injury; similar infiltration of lymphocytes in liver
Refs:
Adachi et al., 2001, J Immunol
Hyperlink: