Molecular group:
Signal transduction and intracellular danger sensors
Molecule/Cell:
MyD88
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for at least 8 generations
Experimental treatment group (EG):
MyD88 -/-
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Less severe hypothermia and no weight loss; resistant to a secondary infection; ↑ IgG1 and similar IgG2a levels; ↓ TNF-a and IFN-g and similar MCP-1 production by splenocytes (in vitro) and in the serum (in vivo) 8 days p.i.; ↓ production of IL-1a, IL-6 (only by DC), TNF-a and IL-12 by CD11b+ macrophages and CD11c+ DC cells in spleen; similar expression of CD40 and CD86 by DC (similar maturation status), ↓ number of ab TCR+, CD4+ and NK cells producing IFN-g and TNF-a; ↓ % op CD25+ and CD69+ CD4+ T cells
Refs:
Franklin et al., 2007, Microbes Infect
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