MyD88

Molecular group: 
Signal transduction and intracellular danger sensors
Molecule/Cell: 
MyD88
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for at least 10 generations
Experimental treatment group (EG): 
MyD88 -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (100%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar neurologic symptoms, thrombocytopenia, neutrophilia and lymphopenia; ↓ anemia; similar ICAM-1 in brain; similar inflammation, edema and parasite sequestration in lung; similar hemozoin deposition and parasite sequestration in liver
Refs: 
Togbe et al., 2007, Am J Pathol