Molecular group:
Signal transduction and intracellular danger sensors
Molecule/Cell:
MyD88
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 8 generations
Experimental treatment group (EG):
MyD88 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (90%)
Pathology (EG):
CM (46.15%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
No red blood cell and leukocyte sequestration in brain microvasculature; no endothelial cell detachment; ↓ hemozoin accumulation in brain vessels; ↓ granzyme B, CCL3 and lipocalin 2 mRNA in brain; ↓ CD4+, CD8+, CCR5+, CD11c+, B220+ and NK1.1+ cells in brain; ↓ serum IL-12p40, IFN-g and TNF-a
Refs:
Coban et al., 2007, Int Immunol
Hyperlink: