Molecular group:
Signal transduction and intracellular danger sensors
Molecule/Cell:
TRIF
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
129/Ola x C57BL/6
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
TRIF -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (91%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar red blood cell and leukocyte sequestration in brain microvasculature; similar endothelial cell detachment; similar granzyme B, CCL3 and lipocalin-2 mRNA in brain; Similar serum IL-12p40, IFN-g and TNF-a
Refs:
Coban et al., 2007, Int Immunol
Hyperlink: