Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
TLR9
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for at least 8 generations
Experimental treatment group (EG):
TLR9 -/-
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar hypothermia and weight loss during peak parasitemia; similar TNF-a and MCP-1 and ↓ IFN-g production by splenocytes 8 days p.i.; similar serum levels of TNF-a, IFN-g and MCP-1 8 days p.i.
Refs:
Franklin et al., 2007, Microbes Infect
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