TLR9

Molecular group: 
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell: 
TLR9
Plasmodium strain: 
Plasmodium chabaudi chabaudi AS
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for at least 8 generations
Experimental treatment group (EG): 
TLR9 -/-
Lethal infection (Con): 
no
Lethal infection (EG): 
no
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar hypothermia and weight loss during peak parasitemia; similar TNF-a and MCP-1 and ↓ IFN-g production by splenocytes 8 days p.i.; similar serum levels of TNF-a, IFN-g and MCP-1 8 days p.i.
Refs: 
Franklin et al., 2007, Microbes Infect