Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
TLR9
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for at least 10 generations
Experimental treatment group (EG):
TLR9 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar neurologic symptoms; similar ICAM-1 in brain; similar inflammation in lung; similar hemozoin deposition in liver
Refs:
Togbe et al., 2007, Am J Pathol
Hyperlink: