Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
TLR9
Plasmodium strain:
Plasmodium chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
TLR9 -/-
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Decreased up-regulation of CD40, CD86 and MHC class II, decreased production of TNF-a and IL-12p70, no degradation of IkB-a and no translocation of NF-kB to the nucleus after incubation of TLR9 -/- DCs with P. berghei or P. chabaudi schizonts; Decreased expression of CD40, CD80 and CD86 on splenic DCs isolated from P. berghei-infected mice 6 days p.i. and P. chabaudi-infected mice 7 days p.i.
Refs:
Seixas et al., 2009, Eur J Immunol
Hyperlink: