Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
TLR2/4/9
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
129/Sv x C57BL/6
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
TLR2/4/9 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (90%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar CD8+CD62Llow and ↓ CD4+CD62Llow T cells in brain; similar ICAM-1 and CD31 in brain; similar IL-12p40 and IL-18 in serum
Refs:
Lepenies et al., 2008, Med Microbial Immunol
Hyperlink: