Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
TLR2/4
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^6
Mouse genetic background (Con):
129 x C57BL/6
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
TLR2/4 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
Liver pathology
Pathology (EG):
Liver pathology
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar serum IL-12 and liver injury
Refs:
Adachi et al., 2001, J Immunol
Hyperlink: