TLR2

Molecular group: 
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell: 
TLR2
Plasmodium strain: 
Plasmodium chabaudi chabaudi AS
pRBC infection titer: 
10^5
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for at least 8 generations
Experimental treatment group (EG): 
TLR2 -/-
Lethal infection (Con): 
no
Lethal infection (EG): 
no
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar hypothermia and weight loss during peak parasitemia; resistant to a secondary infection; similar IgG1 and IgG2a levels; ↓ TNF-a and similar IFN-g and MCP-1 production by splenocytes 8 days p.i.; similar serum levels of TNF-a, IFN-g and MCP-1 8 day
Refs: 
Franklin et al., 2007, Microbes Infect