TLR2

Molecular group: 
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell: 
TLR2
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for at least 10 generations
Experimental treatment group (EG): 
TLR2 -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (100%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar thrombocytopenia, neutrophilia and anemia; ↑ lymphopenia
Refs: 
Togbe et al., 2007, Am J Pathol