Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
Nod1Nod2
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 9 generations
Experimental treatment group (EG):
Nod1Nod2 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (100%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar plasma IFN-g, IL-6 and TNF-a; ↓ plasma IL-1b, MCP-1 (CCL2) and KC (CXCL1-3)
Refs:
Finney et al., 2009, Am J Trop Med Hyg
Hyperlink: