Nod1Nod2

Molecular group: 
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell: 
Nod1Nod2
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
Backcrossed for 9 generations
Experimental treatment group (EG): 
Nod1Nod2 -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (100%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Similar plasma IFN-g, IL-6 and TNF-a; ↓ plasma IL-1b, MCP-1 (CCL2) and KC (CXCL1-3)
Refs: 
Finney et al., 2009, Am J Trop Med Hyg