Scavenger receptors

Molecular group: 
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell: 
Scavenger receptors
Plasmodium strain: 
Plasmodium chabaudi AS
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
Scavenger receptor blockage by Poly(I)
Lethal infection (Con): 
no
Lethal infection (EG): 
no
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Earlier increase in parasitemia, increased peak and similar parasite clearance
Additional phenotypes (EG vs Con): 
↓ phagocytosis of free merozoites (only slight ↓in pRBC phagocytosis); similar serum IL-12p40
Refs: 
Su et al., 2002, J Infect Dis