Molecular group:
Other leucocyte cell surface receptors and membrane transporters
Molecule/Cell:
Scavenger receptors
Plasmodium strain:
Plasmodium chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Scavenger receptor blockage by Poly(I)
Lethal infection (Con):
no
Lethal infection (EG):
no
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Earlier increase in parasitemia, increased peak and similar parasite clearance
Additional phenotypes (EG vs Con):
↓ phagocytosis of free merozoites (only slight ↓in pRBC phagocytosis); similar serum IL-12p40
Refs:
Su et al., 2002, J Infect Dis
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