Molecular group:
Signal transduction and intracellular danger sensors
Molecule/Cell:
Nlrp3
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10 sporozoites
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
Nlrp3 -/-
Lethal infection (Con):
56% (at the end of observation day 20)
Lethal infection (EG):
27% (at the end of observation day 20)
Pathology (Con):
CM (56%)
Pathology (EG):
CM (27%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ leukocyte infiltration, ↓ damaged endothelial cells and ↓ CD45-staining in brain
Refs:
Dostert et al., 2009, PLoS One
Hyperlink: