Molecular group:
Adhesion molecules
Molecule/Cell:
CD62P (P-selectin)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 x 129/Sv
Level of backcrossing:
Backcrossed for 8 generations
Experimental treatment group (EG):
P-selectin -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (80%)
Pathology (EG):
CM (4.5 %)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (2-3 weeks); no neurological symptoms; similar platelet and leukocyte sequestration in brain vessels; chimeric mice lacking endothelial P-selectin were protected whereas chimeric mice lacking platelet P-selectin showed symptoms of CM (57.1 %)
Refs:
Combes et al., 2004, Am J Pathol
Hyperlink: