Molecular group:
Adhesion molecules
Molecule/Cell:
CD62P (P-selectin)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
P-selectin -/-
Lethal infection (Con):
yes
Lethal infection (EG):
80% (at the end of observation day 14)
Pathology (Con):
CM (100%)
Pathology (EG):
CM (80%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (days); ↓leukocyte rolling and similar adhesion on the brain endothelium (also in uninfected P-selectin deficient mice compared to uninfected WT mice)
Refs:
Chang et al., 2003, Infect Immun
Hyperlink: