Molecular group:
Adhesion molecules
Molecule/Cell:
CD54 (ICAM-1)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
ICAM-1-/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (20%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (1-3 weeks); no neurologic symptoms; ↑ blood leukocytes and ↓ thrombocytopenia; ↓ serum TNF-a, similar serum IFN-g and NO3-; ↑ TNF-a mRNA expression in brain, similar TNF-a mRNA expression in lungs and spleen; similar VCAM expression in brain capillaries; similar macrophage accumulation in brain; ↓ macrophage, pRBC and similar PMN, platelet accumulation in lung
Refs:
Favre et al., 1999, Microbes Infect
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