Molecular group:
Adhesion molecules
Molecule/Cell:
CD41/CD61 (gpIIb/IIIa)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CD61 (early treatment)
Lethal infection (Con):
yes
Lethal infection (EG):
60% (at the end of observation day 14)
Pathology (Con):
CM (100%)
Pathology (EG):
CM (60%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ CD41+CD61+, CD41+CD61- and similar CD41-CD61- platelets in circulation
Refs:
Van der Heyde et al., 2005, Blood
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