CD41/CD61 (gpIIb/IIIa)

Molecular group: 
Adhesion molecules
Molecule/Cell: 
CD41/CD61 (gpIIb/IIIa)
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
C57BL/6
Experimental treatment group (EG): 
anti-CD41 (early treatment)
Lethal infection (Con): 
yes
Lethal infection (EG): 
12,5% (at the end of observation day 14)
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (12,5%)
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Prolonged survival (not with late treatment); ↓ CD41+CD61+, CD41-CD61+ and similar CD41-CD61- platelets in circulation; ↑ plasma IL-10, IL-1a, IL-6, IFN-g, TNF-a, fibrinogen,↓ plasma IL-2 and similar plasma factor VII, TF and vWF
Refs: 
Van der Heyde et al., 2005, Blood