Molecular group:
Adhesion molecules
Molecule/Cell:
CD41/CD61 (gpIIb/IIIa)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CD41 (early treatment)
Lethal infection (Con):
yes
Lethal infection (EG):
12,5% (at the end of observation day 14)
Pathology (Con):
CM (100%)
Pathology (EG):
CM (12,5%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (not with late treatment); ↓ CD41+CD61+, CD41-CD61+ and similar CD41-CD61- platelets in circulation; ↑ plasma IL-10, IL-1a, IL-6, IFN-g, TNF-a, fibrinogen,↓ plasma IL-2 and similar plasma factor VII, TF and vWF
Refs:
Van der Heyde et al., 2005, Blood
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