Molecular group:
Adhesion molecules
Molecule/Cell:
CD41/CD61 (gpIIb/IIIa)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CD41 (early treatment)
Lethal infection (Con):
yes
Lethal infection (EG):
9% (at the end of observation day 12)
Pathology (Con):
CM (100%)
Pathology (EG):
CM (9%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival; ↓ CD41+ platelets in circulation
Refs:
Sun et al., 2003, Infect Immun
Hyperlink: