Molecular group:
Adhesion molecules
Molecule/Cell:
CD40L
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^4
Mouse genetic background (Con):
C57BL/6J
Experimental treatment group (EG):
anti-CD40L
Lethal infection (Con):
yes
Lethal infection (EG):
N.I.
Pathology (Con):
CM (100%)
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
↓ thrombocytopenia and hypothermia; some mice had ↓ macrophage sequestration in brain whereas other mice had ↑ macrophage and lymphocyte sequestration
Refs:
Piguet et al., 2001, Am J Pathol
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