CD40L

Molecular group: 
Adhesion molecules
Molecule/Cell: 
CD40L
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
5 x 10^4
Mouse genetic background (Con): 
C57BL/6
Level of backcrossing: 
N.I.
Experimental treatment group (EG): 
CD40L -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
no (at the end of observation day 12)
Pathology (Con): 
CM (100%)
Pathology (EG): 
No CM
Parasitemia (EG vs Con): 
Similar
Additional phenotypes (EG vs Con): 
Prolonged survival (›day 12); ↓ thrombocytopenia and hypothermia; Brain: ↓ macrophage sequestration; ↓ TNF-a and ICAM-1 mRNA expression; ↑ TNF-a and ICAM-1 mRNA expression; Spleen: ↓ splenomegaly; ↑ TNF-a and ICAM-1 mRNA expression
Refs: 
Piguet et al., 2001, Am J Pathol