Molecular group:
Adhesion molecules
Molecule/Cell:
CD40L
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
CD40L -/-
Lethal infection (Con):
yes
Lethal infection (EG):
no (at the end of observation day 12)
Pathology (Con):
CM (100%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (›day 12); ↓ thrombocytopenia and hypothermia; Brain: ↓ macrophage sequestration; ↓ TNF-a and ICAM-1 mRNA expression; ↑ TNF-a and ICAM-1 mRNA expression; Spleen: ↓ splenomegaly; ↑ TNF-a and ICAM-1 mRNA expression
Refs:
Piguet et al., 2001, Am J Pathol
Hyperlink: