Molecular group:
Adhesion molecules
Molecule/Cell:
CD40
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^4
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
CD40 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
no (at the end of observation day 12)
Pathology (Con):
CM (100%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (›day 12); ↓ thrombocytopenia and hypothermia; Brain: ↓ macrophage sequestration; no edema; ↑ TNF-a and ↓ ICAM-1 mRNA expression; Lung: ↓ macrophage sequestration; similar sequestration of pRBCs, PMNs and platelets; no edema; % pRBCs alveolar capillaries › % pRBCs in large blood vessels (similar to WT); ↑ TNF-a and ↓ ICAM-1; Spleen: similar splenomegaly, TNF-a and ↓ ICAM-1 mRNA expression
Refs:
Piguet et al., 2001, Am J Pathol
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