Molecular group:
Adhesion molecules
Molecule/Cell:
CD36
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 x 129/Sv
Level of backcrossing:
Backcrossed for 4 generations
Experimental treatment group (EG):
CD36 -/- chimeras
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (75%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
25 % of CD36 -/- chimeras expressing only CD36 in hematopoietic cells had a prolonged survival (2-3 weeks) without neurological symptoms
Refs:
Cunha-Rodrigues et al., 2007, Malar J
Hyperlink: