CD36

Molecular group: 
Adhesion molecules
Molecule/Cell: 
CD36
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^5 - 10^6
Mouse genetic background (Con): 
C57BL/6 x 129/Sv
Level of backcrossing: 
Backcrossed for 4 generations
Experimental treatment group (EG): 
CD36 -/-
Lethal infection (Con): 
yes
Lethal infection (EG): 
yes
Pathology (Con): 
CM (100%)
Pathology (EG): 
CM (100%)
Parasitemia (EG vs Con): 
Slightly decreased
Additional phenotypes (EG vs Con): 
Similar neurologic symptoms; ↓ schizont sequestration in adipose and lung tissue; no schizont sequestration in brain (similar to WT); ↑ parasite accumulation in spleen (↑ pRBC clearance?); ↑ number of schizonts in peripheral blood
Refs: 
Franke-Fayard et al., 2005, Proc Natl Acad Sci U S A