Molecular group:
Adhesion molecules
Molecule/Cell:
b2 integrin (CD18)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^4
Mouse genetic background (Con):
C57BL/6J
Level of backcrossing:
N.I.
Experimental treatment group (EG):
CD18 -/-
Lethal infection (Con):
N.I.
Lethal infection (EG):
N.I.
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
↑ LN cellularity; similar splenomegaly; no significant apoptosis in white pulp (spleen) and LN
Refs:
Piguet et al. 2001, Dev Immunol
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