Molecular group:
Chemokines and receptors
Molecule/Cell:
CXCR3
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
2 x 10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
in vitro activated WT and CXCR3 -/- effector CD8+ T cells (day 5)
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
CM
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Similar number of WT and CXCR3 -/- cells in spleen and ↓ number of CXCR3 -/- cells in brain after competitive (co)transfer in WT mice
Refs:
Campanella et al., 2008, Proc Natl Acad Sci U S A
Hyperlink: