CXCR3

Molecular group: 
Chemokines and receptors
Molecule/Cell: 
CXCR3
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
2 x 10^6
Mouse genetic background (Con): 
CXCR3 -/-
Level of backcrossing: 
Backcrossed for 10 generations
Experimental treatment group (EG): 
adoptive transfer of in vivo activated WT splenocytes or CD8+ T cells (day 0)
Lethal infection (Con): 
30% (at the end of observation day 20)
Lethal infection (EG): 
70-90% (at the end of observation day 20)
Pathology (Con): 
CM (30%)
Pathology (EG): 
CM (70-90%)
Parasitemia (EG vs Con): 
N.I.
Additional phenotypes (EG vs Con): 
↑ number of WT (adoptively transferred) and CXCR3 -/- (own) CD8+ T cells in brain at the CM stage; ↑ IP-10, MIG, RANTES, MCP-1 and IFN-g mRNA expression in brain (similar to WT mice)
Refs: 
Campanella et al., 2008, Proc Natl Acad Sci U S A