Molecular group:
Chemokines and receptors
Molecule/Cell:
CXCR3
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
2 x 10^6
Mouse genetic background (Con):
CXCR3 -/-
Level of backcrossing:
Backcrossed for 10 generations
Experimental treatment group (EG):
adoptive transfer of in vivo activated WT splenocytes or CD8+ T cells (day 0)
Lethal infection (Con):
30% (at the end of observation day 20)
Lethal infection (EG):
70-90% (at the end of observation day 20)
Pathology (Con):
CM (30%)
Pathology (EG):
CM (70-90%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
↑ number of WT (adoptively transferred) and CXCR3 -/- (own) CD8+ T cells in brain at the CM stage; ↑ IP-10, MIG, RANTES, MCP-1 and IFN-g mRNA expression in brain (similar to WT mice)
Refs:
Campanella et al., 2008, Proc Natl Acad Sci U S A
Hyperlink: