Molecular group:
Chemokines and receptors
Molecule/Cell:
CXCR3
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 11 generations
Experimental treatment group (EG):
CXCR3 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (32%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (1–3 weeks); no neurological symptoms or recovered from neurological symptoms; ↓ CXCL9 (MIG), CXCL10 (IP-10) and CCL5 (RANTES) mRNA expression in the brain; ↓ sequestered CD8+ T cells and CD4+ T cells, similar NK, NKT and CD11b+ cells in the brain; ↓ IP-10, perforin, FasL, IFN-g and LT-a and similar ICAM-1 mRNA expression in the brain; similar IFN-g mRNA expression in the spleen
Refs:
Miu et al., 2008, J Immunol
Hyperlink: