Molecular group:
Chemokines and receptors
Molecule/Cell:
CXCR3
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
2 x 10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 10 generations
Experimental treatment group (EG):
CXCR3 -/-
Lethal infection (Con):
90% (at the end of observation day 23)
Lethal infection (EG):
10-30% (at the end of observation day 23)
Pathology (Con):
CM (90%)
Pathology (EG):
CM (10-30%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (1–3 weeks); no neurological symptoms; ↓ CD8+ T cells and NK cells and similar NKT cells in the brain; ↓ CXCL9 (MIG), CXCL10 (IP-10), CCL5 (RANTES), CCL2 (MCP-1) and IFN-g expression in the brain
Refs:
Campanella et al., 2008, Proc Natl Acad Sci U S A
Hyperlink: