Molecular group:
Chemokines and receptors
Molecule/Cell:
CCR5
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6 x 129/Ola
Level of backcrossing:
Mixed background (50%)
Experimental treatment group (EG):
CCR5 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (70-80%)
Pathology (EG):
CM (20%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (1-3 weeks); similar anemia; no neurologic symptoms; ↓ leukocyte sequestration in brain; no IFN-g and ↓ TNF-a in serum; ↓ incidence of CM (or ↑ incidence) by adoptive transfer of bone marrow from CCR5 -/- (or WT) into irradiated WT (or CCR5 -/-) mice
Refs:
Belnoue et al., 2003, Blood
Hyperlink: