Molecular group:
Chemokines and receptors
Molecule/Cell:
CXCL12 (SDF-1a)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
BALB/c
Experimental treatment group (EG):
SDF-1a
Lethal infection (Con):
N.I.
Lethal infection (EG):
N.I.
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Decreased
Additional phenotypes (EG vs Con):
Similar number of CD11c+ cells in the bone marrow 14 days p.i.; ↑ numbers of cd11c+CD8a+ and CD11c+CD11b+ cells in the spleen 14 days p.i.; induction of periarteriolar CD11c clustering in the spleen
Refs:
Garnica et al., 2005, Immunology
Hyperlink: