CXCL12 (SDF-1a)

Molecular group: 
Chemokines and receptors
Molecule/Cell: 
CXCL12 (SDF-1a)
Plasmodium strain: 
Plasmodium berghei ANKA
pRBC infection titer: 
10^6
Mouse genetic background (Con): 
BALB/c
Experimental treatment group (EG): 
SDF-1a
Lethal infection (Con): 
N.I.
Lethal infection (EG): 
N.I.
Pathology (Con): 
N.I.
Pathology (EG): 
N.I.
Parasitemia (EG vs Con): 
Decreased
Additional phenotypes (EG vs Con): 
Similar number of CD11c+ cells in the bone marrow 14 days p.i.; ↑ numbers of cd11c+CD8a+ and CD11c+CD11b+ cells in the spleen 14 days p.i.; induction of periarteriolar CD11c clustering in the spleen
Refs: 
Garnica et al., 2005, Immunology