Molecular group:
Chemokines and receptors
Molecule/Cell:
CXCL10 (IP-10)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CXCL10 (d5-9)
Lethal infection (Con):
yes
Lethal infection (EG):
50% (at the end of observation day 17)
Pathology (Con):
CM (100%)
Pathology (EG):
CM (50%)
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
Prolonged survival (at least until day 17); no neurological symptoms
Refs:
Nie et al., 2009, PLoS Pathog
Hyperlink: