Molecular group:
Chemokines and receptors
Molecule/Cell:
CXCL10 (IP-10)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-CXCL10 (d3-9)
Lethal infection (Con):
yes
Lethal infection (EG):
20% (at the end of observation day 20)
Pathology (Con):
CM (100%)
Pathology (EG):
CM (20%)
Parasitemia (EG vs Con):
Decreased on day 5
Additional phenotypes (EG vs Con):
Prolonged survival (at least until day 20); no neurological symptoms; ↓ blood vessels with intravascular inflammation; similar pRBC sequestration and ↓ CD4+ and CD8+ T cells (similar NK cells); majority of brain infiltrating T cells were CXCR3+ and CCR5-, indicating that other CXCR3 chemokines (MIG and I-TAC) can still recruit CXCR3+ T cells to the brain; similar expression of CD25 and CD69 activation markers in brain sequestering T cells and cells could still migrate to recombinant IP-10 in a chemotaxis assay; ↑ parasite-specific proliferation of CD4+ T cells; similar number of CXCR3+/IFN-g+CD4+ and CXCR3+/IFN-g+CD8+ T cells in spleen
Refs:
Nie et al., 2009, PLoS Pathog
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