Molecular group:
Chemokines and receptors
Molecule/Cell:
CXCL10 (IP-10)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 9 generations
Experimental treatment group (EG):
CXCL10 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
5% (at the end of observation day 20)
Pathology (Con):
CM (100%)
Pathology (EG):
CM (5%)
Parasitemia (EG vs Con):
Decreased
Additional phenotypes (EG vs Con):
Prolonged survival (at least until day 20); no neurological symptoms; ↓ blood vessels with intravascular inflammation; ↓ pRBC, CD4+ and CD8+ T cell sequestration (similar NK cells); similar ICAM-1+ blood vessels; ↑ parasite-specific proliferation and IFN-g production by CD4+ T cells; ↑ number of CXCR3+/IFN-g+CD4+ and CXCR3+/IFN-g+CD8+ T cells in spleen; ↓ IFN-g in serum; anti-IFN-g treatment had no effect on reduced parasitemia
Refs:
Nie et al., 2009, PLoS Pathog
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