Molecular group:
Chemokines and receptors
Molecule/Cell:
CXCL4 (PF-4)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
PF4 -/-
Level of backcrossing:
Backcrossed for more than 10 generations
Experimental treatment group (EG):
rPF-4
Lethal infection (Con):
30% (at the end of observation day 10)
Lethal infection (EG):
80% (at the end of observation day 10)
Pathology (Con):
CM (30%)
Pathology (EG):
CM (80%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
N.I.
Refs:
Srivastava et al., 2008, Cell Host Microbe
Hyperlink: