Molecular group:
Chemokines and receptors
Molecule/Cell:
CXCL4 (PF-4)
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
5 x 10^5
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for more than 10 generations
Experimental treatment group (EG):
PF-4 -/-
Lethal infection (Con):
70% (at the end of observation day 10)
Lethal infection (EG):
30% (at the end of observation day 10)
Pathology (Con):
CM (70%)
Pathology (EG):
CM (30%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
No neurological symptoms; no ↑ plasma TNF-a or IFN-g 5 days p.i.; no ↑ CXCR3 expression by splenocyt-derived T cells; no↑ number of CD4+ or CD8+ T cells in brain
Refs:
Srivastava et al., 2008, Cell Host Microbe
Hyperlink: