Molecular group:
Cytokines and receptors
Molecule/Cell:
TGF-b
Plasmodium strain:
Plasmodium berghei NK65
pRBC infection titer:
10^4
Mouse genetic background (Con):
BALB/c
Experimental treatment group (EG):
rTGF-b
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Delayed onset
Additional phenotypes (EG vs Con):
Dose-dependent delay of mortality (2-3 weeks); ↓ serum TNF-a and IL-4; ↑serum IFN-g and IL-10
Refs:
Omer et al., 1998, J Exp Med
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