Molecular group:
Cytokines and receptors
Molecule/Cell:
TGF-b/IL-10R
Plasmodium strain:
Plasmodium yoelii 17XL
pRBC infection titer:
10^5
Mouse genetic background (Con):
C57BL/6
Experimental treatment group (EG):
anti-TGF-b + anti-IL-10R
Lethal infection (Con):
yes
Lethal infection (EG):
60% (at the end of observation day 34)
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Complete parasite clearance
Additional phenotypes (EG vs Con):
↑ plasma TNF-a and slightly ↑ plasma IFN-g
Refs:
Omer et al., 2003, J Immunol
Hyperlink: