Molecular group:
Cytokines and receptors
Molecule/Cell:
TGF-b
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
5 x 10^4
Mouse genetic background (Con):
BALB/c Cr Slc
Experimental treatment group (EG):
anti-TGF-b
Lethal infection (Con):
yes
Lethal infection (EG):
20%
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Slightly lower peak and spontaneous decline
Additional phenotypes (EG vs Con):
↑ serum IFN-g (day 7) and NO (day 10)
Refs:
Tsutsui et al., 1999, Infect Immun
Hyperlink: