Molecular group:
Cytokines and receptors
Molecule/Cell:
LTbR/testosterone
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
LTbR -/- (C57BL/6)
Level of backcrossing:
N.I.
Experimental treatment group (EG):
testosterone
Lethal infection (Con):
♀3%
Lethal infection (EG):
♀ yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Increased peak, no clearance
Additional phenotypes (EG vs Con):
Delayed reticulocytosis and similar anemia; similar numbers of CD4+, CD8+, B220+ and F4/80+ cells in spleen;↑ IFN-g, IP-10, MCP-1, CD71, TIMP3, CTGF, BST1 and CTLA4 mRNA expression in the spleen, similar serum bilirubin, LDH, AST, ALT and ↓ AP; ↓ CCL5 and ↑ CCL2, CXCL10, CXCL9 PAI1, NF-IL3A and TIMP3 liver RNA
Refs:
Wunderlich et al., 2005, Microbes Infect
Hyperlink: