Molecular group:
Cytokines and receptors
Molecule/Cell:
LTbR
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 5 generations
Experimental treatment group (EG):
LTbR -/-
Lethal infection (Con):
♂ yes
Lethal infection (EG):
♂ yes
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Similar reticulocytosis and anemia; castration protects WT mice but not LTbR -/- deficient mice from a lethal infection
Refs:
Krücken et al., 2005, Parasite Immunol
Hyperlink: