Molecular group:
Cytokines and receptors
Molecule/Cell:
LTbR
Plasmodium strain:
Plasmodium chabaudi chabaudi AS
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
N.I.
Experimental treatment group (EG):
LTbR -/-
Lethal infection (Con):
♀24%
Lethal infection (EG):
♀ 3 %
Pathology (Con):
N.I.
Pathology (EG):
N.I.
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Earlier increase of reticulocytosis; shorter period of anemia; similar numbers of CD4+, CD8+, B220+ and F4/80+ cells in spleen; mice became susceptible after treatment with testosterone
Refs:
Wunderlich et al., 2005, Microbes Infect
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