Molecular group:
Cytokines and receptors
Molecule/Cell:
LTbR
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6J
Level of backcrossing:
Backcrossed for at least 10 generations
Experimental treatment group (EG):
LTbR -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
No CM
Parasitemia (EG vs Con):
Increased
Additional phenotypes (EG vs Con):
No neurologic symptoms: normal bloodflow and brain morphology, no brain swelling or edema, no mononuclear cell sequestration or hemorrhaging; ↓ perforin+CD8+, CD54+CD8+ and CD69+CD8+ T cells in brain; lung pathology: ↓ pRBC sequestration and similar thickening of alveolar septae; similar thrombocytopenia; no platelet adherence to cerebrovascular endothelium; similar ↓ in peripheral lymphocytes; anemia; lethal irradiation of LTbR KO or WT mice and subsequent reconstitution with bone marrow from WT or LTbR KO mice could not abolish or confer protection, respectively
Refs:
Togbe et al., 2008, PLoS One
Hyperlink: