Molecular group:
Cytokines and receptors
Molecule/Cell:
LTa
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6J
Level of backcrossing:
N.I.
Experimental treatment group (EG):
LTa -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM
Pathology (EG):
No CM
Parasitemia (EG vs Con):
N.I.
Additional phenotypes (EG vs Con):
No neurologic symptoms; ↑ levels (normal values) of [31P]-containing metabolites (phosphocreatinine (PCr), b-ATP and PCr:PME), similar levels (normal values) of phosphomonoesters (PME), and ↓ levels (normal values) of inorganic phosphate (Pi), Pi:b-ATP and Pi:PCr in brain 6-7 days p.i.; ↑ lactate, GABA and aspartate, and normal glutamate, alanine, NAA and glutamine metabolite pool sizes in brain (compared with uninfected LT-a -/- mice), however uninfected LT-a -/- mice had significantly different metabolite levels compared to uninfected WT, IFN-g -/-and TNF-a -/- mice, and brain lactate levels were ↑ but not to the same level as infected WT mice; no ↓ brain net flux of 13C from D-[1-13C]glucose into metabolic intermediates associated with Krebs cycle (normal compared to uninfected LT-a -/- mice), except for Ala C3 which did not change upon infection
Refs:
Parekh et al., 2006, Int J Parasitol
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