Molecular group:
Cytokines and receptors
Molecule/Cell:
LTa
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6J
Level of backcrossing:
Backcrossed for at least 10 generations
Experimental treatment group (EG):
LTa -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (100%)
Pathology (EG):
CM (10- 20%)
Parasitemia (EG vs Con):
Increased
Additional phenotypes (EG vs Con):
No neurologic symptoms; anemia
Refs:
Togbe et al., 2008, PLoS One
Hyperlink: