Molecular group:
Cytokines and receptors
Molecule/Cell:
TNFR2
Plasmodium strain:
Plasmodium berghei ANKA
pRBC infection titer:
10^6
Mouse genetic background (Con):
C57BL/6
Level of backcrossing:
Backcrossed for 6 generations
Experimental treatment group (EG):
TNFR2 -/-
Lethal infection (Con):
yes
Lethal infection (EG):
yes
Pathology (Con):
CM (90%)
Pathology (EG):
CM (25%)
Parasitemia (EG vs Con):
Similar
Additional phenotypes (EG vs Con):
Prolonged survival (2-3 weeks); no neurological symptoms; no platelet staining in brain
Refs:
Stoelcker et al., 2002, Infect Immun
Hyperlink: